CD79a Polyclonal Antibody, 100µg, (ATB-T0778)

Background: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.Product datasheet: Overview Product Description CD79a Polyclonal Antibody, 100µg, (ATB-T0778) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the C-terminal region of human CD79a. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Structure and expression of the mb-1 transcript in human lymphoid cells. Leduc I., Preud'Homme J.L., Cogne M.Clin. Exp. Immunol. 90:141-146(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Cloning and sequencing of the cDNA encoding the human homologue of the murine immunoglobulin-associated protein B29. Mueller B.S., Cooper L., Terhorst C.Eur. J. Immunol. 22:1621-1625(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Tonsil. Molecular cloning of the Ig-alpha subunit of the human B-cell antigen receptor complex. Flaswinkel H., Reth M.Immunogenetics 36:266-269(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Human mb-1 gene: complete cDNA sequence and its expression in B cells bearing membrane Ig of various isotypes. Yu L.M., Chang T.W.J. Immunol. 148:633-637(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Molecular cloning and expression pattern of a human gene homologous to the murine mb-1 gene. Ha H.J., Kubagawa H., Burrows P.D.J. Immunol. 148:1526-1531(1992) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1). Chromosomal localization, genomic structure, and allelic polymorphism of the human CD79 alpha (Ig-alpha/mb-1) gene. Hashimoto S., Mohrenweiser H.W., Gregersen P.K., Chiorazzi N.Immunogenetics 40:287-295(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Structure, chromosomal localization, and methylation pattern of the human mb-1 gene. Ha H., Barnoski B.L., Sun L., Emanuel B.S., Burrows P.D.J. Immunol. 152:5749-5757(1994) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. Hashimoto S., Chiorazzi N., Gregersen P.K.Mol. Immunol. 32:651-659(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Koyama M., Nakamura T.Submitted (DEC-1994) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Small intestine.