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CEP57 Polyclonal Antibody, 100μg, (ATB-T0863)
Background: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]Product datasheet: Overview Product Description CEP57 Polyclonal Antibody, 100μg, (ATB-T0863) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CEP57. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Cep57, a NEDD1-binding pericentriolar material component, is essential for spindle pole integrity. Wu Q, et al. Cell Res, 2012 Sep. PMID 22508265 Free PMC Article Mutations in CEP57 cause mosaic variegated aneuploidy syndrome. Snape K, et al. Nat Genet, 2011 Jun. PMID 21552266 Free PMC Article Cep57 protein is required for cytokinesis by facilitating central spindle microtubule organization. He R, et al. J Biol Chem, 2013 May 17. PMID 23569207 Free PMC Article Selective chemical crosslinking reveals a Cep57-Cep63-Cep152 centrosomal complex. Lukinavičius G, et al. Curr Biol, 2013 Feb 4. PMID 23333316 FGF-2 disrupts mitotic stability in prostate cancer through the intracellular trafficking protein CEP57. Cuevas R, et al. Cancer Res, 2013 Feb 15. PMID 23243019
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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