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CHOP Polyclonal Antibody, 100μg, (ATB-T0912)

CHOP Polyclonal Antibody, 100μg, (ATB-T0912)

Store / Antibodies and Immunodetection Reagents / Primary Antibodies
$199.00
In stock
Product Details

Background: This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]Product datasheet: Overview Product Description CHOP Polyclonal Antibody, 100μg, (ATB-T0912) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human CHOP around the non-phosphorylation site of S30. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification. Miyazaki-Anzai S, et al. J Am Heart Assoc, 2014 Jun 24. PMID 24963104 Free PMC Article DDIT3 overexpression increases odontoblastic potential of human dental pulp cells. Wu Y, et al. Cell Prolif, 2014 Jun. PMID 24738922 Stronger proteasomal inhibition and higher CHOP induction are responsible for more effective induction of paraptosis by dimethoxycurcumin than curcumin. Yoon MJ, et al. Cell Death Dis, 2014 Mar 13. PMID 24625971 Free PMC Article Rosemary (Rosmarinus officinalis) extract modulates CHOP/GADD153 to promote androgen receptor degradation and decreases xenograft tumor growth. Petiwala SM, et al. PLoS One, 2014. PMID 24598693 Free PMC Article Stressing the importance of CHOP in liver cancer. Updegraff BL, et al. PLoS Genet, 2013. PMID 24367283 Free PMC Article

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CHOP Polyclonal Antibody, 100μg, (ATB-T0912)
Store / Antibodies and Immunodetection Reagents / Primary Antibodies
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