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CLC-6 Polyclonal Antibody, 100μg, (ATB-T0960)

$199.00
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Product Details

Background: This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]Product datasheet: Overview Product Description CLC-6 Polyclonal Antibody, 100μg, (ATB-T0960) Image Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from the Internal region of human CLC-6. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression. Neagoe I, et al. J Biol Chem, 2010 Jul 9. PMID 20466723 Free PMC Article Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains. Ignoul S, et al. PLoS One, 2007 May 30. PMID 17534424 Free PMC Article Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array. Tomaszewski M, et al. Hypertension, 2010 Dec. PMID 21060006 Free PMC Article The exon-intron architecture of human chloride channel genes is not conserved. Eggermont J. Biochim Biophys Acta, 1998 Apr 29. PMID 9565675 Alternative splicing of ClC-6 (a member of the CIC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific. Eggermont J, et al. Biochem J, 1997 Jul 1. PMID 9224655 Free PMC Article

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CLC-6 Polyclonal Antibody, 100μg, (ATB-T0960)
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