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CNG-1 Polyclonal Antibody, 100μg, (ATB-T0995)

$199.00
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Background: The protein encoded by this gene is involved in phototransduction. Along with another protein, the encoded protein forms a cGMP-gated cation channel in the plasma membrane, allowing depolarization of rod photoreceptors. This represents the last step in the phototransduction pathway. Defects in this gene are a cause of retinitis pigmentosa autosomal recessive (ARRP) disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]Product datasheet: Overview Product Description CNG-1 Polyclonal Antibody, 100μg, (ATB-T0995) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human CNG-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Autosomal recessive retinitis pigmentosa in a Pakistani family mapped to CNGA1 with identification of a novel mutation. Zhang Q, et al. Mol Vis, 2004 Nov 17. PMID 15570217 Novel homozygous mutation in the alpha subunit of the rod cGMP gated channel (CNGA1) in two Spanish sibs affected with autosomal recessive retinitis pigmentosa. Paloma E, et al. J Med Genet, 2002 Oct. PMID 12362048 Free PMC Article Human rod cGMP-gated cation channel gene maps to 4p12-->centromere by chromosomal in situ hybridization. Griffin CA, et al. Genomics, 1993 Apr. PMID 7683629 Human rod photoreceptor cGMP-gated channel: amino acid sequence, gene structure, and functional expression. Dhallan RS, et al. J Neurosci, 1992 Aug. PMID 1379636 Identification and characterization of a partial cDNA expressing interleukin-1-like activity in keratinocytes. Arsenault TV, et al. Mol Immunol, 1992 Mar. PMID 1372959

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CNG-1 Polyclonal Antibody, 100μg, (ATB-T0995)
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