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COL17A1 Polyclonal Antibody, 100μg, (ATB-T1014)
Background: This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description COL17A1 Polyclonal Antibody, 100μg, (ATB-T1014) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the N-terminal region of human COL17A1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Pigmentation and melanocyte supply to the epidermis depend on type XVII collagen. Gostyński A, et al. Exp Dermatol, 2014 Feb. PMID 24330315 The missense mutation p.R1303Q in type XVII collagen underlies junctional epidermolysis bullosa resembling Kindler syndrome. Has C, et al. J Invest Dermatol, 2014 Mar. PMID 24005051 Bullous pemphigoid IgG induces BP180 internalization via a macropinocytic pathway. Hiroyasu S, et al. Am J Pathol, 2013 Mar. PMID 23337823 Free PMC Article Association of autoantibodies to BP180 with disease activity in Greek patients with bullous pemphigoid. Patsatsi A, et al. Clin Dev Immunol, 2012. PMID 23227089 Free PMC Article Collagen XVII (BP180) modulates keratinocyte expression of the proinflammatory chemokine, IL-8. Van den Bergh F, et al. Exp Dermatol, 2012 Aug. PMID 22775995 Free PMC Article
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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What products do you offer?
At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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