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CPM Polyclonal Antibody, 100μg, (ATB-T1088)

$199.00
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Background: The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CPM Polyclonal Antibody, 100μg, (ATB-T1088) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CPM. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Mapping of carboxypeptidase m in normal human kidney and renal cell carcinoma: expression in tumor-associated neovasculature and macrophages. Denis CJ, et al. J Histochem Cytochem, 2013 Mar. PMID 23172796 Free PMC Article Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells. Tsakiris I, et al. Lab Invest, 2012 Mar. PMID 22157720 Free PMC Article Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma. Erickson-Johnson MR, et al. Mod Pathol, 2009 Dec. PMID 19820690 Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. Reverter D, et al. J Mol Biol, 2004 Apr 23. PMID 15066430 Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. Tan F, et al. Biochem J, 2003 Mar 1. PMID 12457462 Free PMC Article

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CPM Polyclonal Antibody, 100μg, (ATB-T1088)
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