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CRF-RII Polyclonal Antibody, 100μg, (ATB-T1110)

$199.00
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Product Details

Background: The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]Product datasheet: Overview Product Description CRF-RII Polyclonal Antibody, 100μg, (ATB-T1110) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human CRF-RII. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Estrogen up-regulates CRHR2 expression via demethylation of CRHR2 gene promoter in cardiomyocytes. Cong B, et al. Int J Cardiol, 2014 Mar 15. PMID 24485608 Corticotropin releasing hormone receptor 2 (CRHR-2) gene is associated with decreased risk and severity of posttraumatic stress disorder in women. Wolf EJ, et al. Depress Anxiety, 2013 Dec. PMID 24123648 Free PMC Article Corticotropin-releasing factor receptor subtype 2 in human colonic mucosa: down-regulation in ulcerative colitis. Chatzaki E, et al. World J Gastroenterol, 2013 Mar 7. PMID 23539366 Free PMC Article Molecular determinants and feedback circuits regulating type 2 CRH receptor signal integration. Markovic D, et al. Biochim Biophys Acta, 2011 May. PMID 21338628 Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor. Pal K, et al. J Biol Chem, 2010 Dec 17. PMID 20966082 Free PMC Article

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CRF-RII Polyclonal Antibody, 100μg, (ATB-T1110)
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