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CRSP77 Polyclonal Antibody, 100μg, (ATB-T1124)
Background: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CRSP77 Polyclonal Antibody, 100μg, (ATB-T1124) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the Internal region of human CRSP77. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Infantile cerebral and cerebellar atrophy is associated with a mutation in the MED17 subunit of the transcription preinitiation mediator complex. Kaufmann R, et al. Am J Hum Genet, 2010 Nov 12. PMID 20950787 Free PMC Article Mediator and post-recruitment regulation of RNA polymerase II. Knuesel MT, et al. Transcription, 2011 Jan-Feb. PMID 21326907 Free PMC Article Role of metazoan mediator proteins in interferon-responsive transcription. Lau JF, et al. Mol Cell Biol, 2003 Jan. PMID 12509459 Free PMC Article The BRCA1 and BARD1 association with the RNA polymerase II holoenzyme. Chiba N, et al. Cancer Res, 2002 Aug 1. PMID 12154023 The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Stumpf M, et al. Proc Natl Acad Sci U S A, 2006 Dec 5. PMID 17132730 Free PMC Article
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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