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CYP4B1 Polyclonal Antibody, 100μg, (ATB-T1233)

$199.00
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Background: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolize certain carcinogens; however, the specific function of the human protein has not been determined. Two transcript variants encoding slightly different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CYP4B1 Polyclonal Antibody, 100μg, (ATB-T1233) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human CYP4B1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Possible relationship between the risk of Japanese bladder cancer cases and the CYP4B1 genotype. Sasaki T, et al. Jpn J Clin Oncol, 2008 Sep. PMID 18713828 Human CYP4B1 gene in the japanese population analyzed by denaturing HPLC. Hiratsuka M, et al. Drug Metab Pharmacokinet, 2004 Apr. PMID 15499177 Retinoic acid induces corneal epithelial CYP4B1 gene expression and stimulates the synthesis of inflammatory 12-hydroxyeicosanoids. Ashkar S, et al. J Ocul Pharmacol Ther, 2004 Feb. PMID 15006160 Genetic polymorphism of the human cytochrome P450 CYP4B1: evidence for a non-functional allelic variant. Lo-Guidice JM, et al. Pharmacogenetics, 2002 Jul. PMID 12142726 The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. Iscan M, et al. Breast Cancer Res Treat, 2001 Nov. PMID 11767004

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CYP4B1 Polyclonal Antibody, 100μg, (ATB-T1233)
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