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Caldesmon Polyclonal Antibody, 100μg, (ATB-T0608)

$199.00
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Background: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Caldesmon Polyclonal Antibody, 100μg, (ATB-T0608) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Caldesmon around the non-phosphorylation site of S789. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Caldesmon: new insights for diagnosing endometriosis. Meola J, et al. Biol Reprod, 2013 May. PMID 23575144 Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein. Hou Q, et al. J Proteome Res, 2013 Feb 1. PMID 23265641 Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases. Köhler C. Virchows Arch, 2011 Jul. PMID 21626272 Immunohistochemical characteristics of atypical polypoid adenomyoma with special reference to h-caldesmon. Horita A, et al. Int J Gynecol Pathol, 2011 Jan. PMID 21131830 Caldesmon over-expression in type 1 diabetic nephropathy. Millioni R, et al. J Diabetes Complications, 2011 Mar-Apr. PMID 20801058

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Caldesmon Polyclonal Antibody, 100μg, (ATB-T0608)