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Claudin-6 Polyclonal Antibody, 100μg, (ATB-T0954)
Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]Product datasheet: Overview Product Description Claudin-6 Polyclonal Antibody, 100μg, (ATB-T0954) Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from human Claudin-6 around the non-phosphorylation site of Y219. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Immunologic and chemical targeting of the tight-junction protein Claudin-6 eliminates tumorigenic human pluripotent stem cells. Ben-David U, et al. Nat Commun, 2013. PMID 23778593 Claudin-6 is a nonspecific marker for malignant rhabdoid and other pediatric tumors. Sullivan LM, et al. Am J Surg Pathol, 2012 Jan. PMID 21989342 Free PMC Article [Effects of 17β-estradiol on proliferation and migration of MCF-7 cell by regulating expression of claudin-6]. Liu YF, et al. Zhonghua Bing Li Xue Za Zhi, 2010 Jan. PMID 20388399 [Effects of stable up-regulation of tight junction protein claudin-6 upon biological phenotypes of breast cancer cell MCF-7]. Wu Q, et al. Zhonghua Yi Xue Za Zhi, 2010 Feb 9. PMID 20367941 Tight junction protein, claudin-6, downregulates the malignant phenotype of breast carcinoma. Wu Q, et al. Eur J Cancer Prev, 2010 May. PMID 20215972
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
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