Cleaved-Integrin α5 LC (E895) Polyclonal Antibody, 100µg, (ATB-C0089)

Background: Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.Product datasheet: Overview Product Description Cleaved-Integrin α5 LC (E895) Polyclonal Antibody, 100µg, (ATB-C0089) Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human Integrin α5 LC. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Amino acid sequence of the human fibronectin receptor. Argraves W.S., Suzuki S., Arai H., Thompson K., Pierschbacher M.D., Ruoslahti E.J. Cell Biol. 105:1183-1190(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta. The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter. Birkenmeier T.M., McQuillan J.J., Boedeker E.D., Argraves W.S., Ruoslahti E., Dean D.C.J. Biol. Chem. 266:20544-20549(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73. Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb. Fitzgerald L.A., Poncz M., Steiner B., Rall S.C., Bennett J.S., Phillips D.R.Biochemistry 26:8158-8165(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-1049. cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide. Argraves W.S., Pytela R., Suzuki S., Millan J.L., Pierschbacher M.D., Ruoslahti E.J. Biol. Chem. 261:12922-12924(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 821-1049. The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis. Takada Y., Strominger J.L., Hemler M.E.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 42-55. The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor. Barillari G., Sgadari C., Fiorelli V., Samaniego F., Colombini S., Manzari V., Modesti A., Nair B.C., Cafaro A., Stuerzl M., Ensoli B.Blood 94:663-672(1999) [PubMed] [Europe PMC] Cited for: INTERACTION WITH HIV-1 TAT. Insulin receptor substrate 4 associates with the protein IRAS. Sano H., Liu S.C.H., Lane W.S., Piletz J.E., Lienhard G.E.J. Biol. Chem. 277:19439-19447(2002) [PubMed] [Europe PMC] Cited for: INTERACTION WITH NISCH. Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains. Krokhin O.V., Cheng K., Sousa S.L., Ens W., Standing K.G., Wilkins J.A.Biochemistry 42:12950-12959(2003) [PubMed] [Europe PMC] Cited for: DISULFIDE BONDS. Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. Chen F.-H., Thomas A.O., Hecht J.T., Goldring M.B., Lawler J.J. Biol. Chem. 280:32655-32661(2005) [PubMed] [Europe PMC] Cited for: INTERACTION WITH COMP.