Cleaved-Notch 4 (V1432) Polyclonal Antibody, 100μg, (ATB-C0071)

Background: This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Cleaved-Notch 4 (V1432) Polyclonal Antibody, 100μg, (ATB-C0071) Image Species Reactivities Human,Monkey Immunogen Synthesized peptide derived from the C-terminal region of human Notch 4. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: NOTCH4 is a potential therapeutic target for triple-negative breast cancer. Nagamatsu I, et al. Anticancer Res, 2014 Jan. PMID 24403446 Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations. ZhuGe Q, et al. J Cell Mol Med, 2013 Nov. PMID 24373503 Free PMC Article Genetic variants in the NOTCH4 gene influence the clinical features of migraine. Rubino E, et al. J Headache Pain, 2013 Mar 26. PMID 23566281 Free PMC Article A NOTCH4 missense mutation confers resistance to multiple sclerosis in Japanese. Huang J, et al. Mult Scler, 2013 Nov. PMID 23549433 Lentiviral-mediated gene silencing of Notch-4 inhibits in vitro proliferation and perineural invasion of ACC-M cells. Chen W, et al. Oncol Rep, 2013 May. PMID 23450325