Crystallin-αB Polyclonal Antibody, 100μg, (ATB-T1125)

Background: Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]Product datasheet: Overview Product Description Crystallin-αB Polyclonal Antibody, 100μg, (ATB-T1125) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Crystallin-αB around the non-phosphorylation site of S19. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Prevention of aberrant protein aggregation by anchoring the molecular chaperone αB-crystallin to the endoplasmic reticulum. Yamamoto S, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25449278 A novel P20R mutation in the alpha-B crystallin gene causes autosomal dominant congenital posterior polar cataracts in a Chinese family. Xia XY, et al. BMC Ophthalmol, 2014 Sep 8. PMID 25195561 Free PMC Article Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma. van de Schootbrugge C, et al. BMC Cancer, 2014 Apr 11. PMID 24725344 Free PMC Article The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Hochberg GK, et al. Proc Natl Acad Sci U S A, 2014 Apr 22. PMID 24711386 Free PMC Article Alpha B-crystallin - a validated prognostic factor for poor prognosis in squamous cell carcinoma of the oral cavity. Annertz K, et al. Acta Otolaryngol, 2014 May. PMID 24702231