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CyPA Polyclonal Antibody, 100μg, (ATB-T15197)

$199.00
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Product Details

Background: This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description CyPA Polyclonal Antibody, 100μg, (ATB-T15197) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human CyPA. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism. Camilloni C, et al. Proc Natl Acad Sci U S A, 2014 Jul 15. PMID 24982184 Free PMC Article Plasma level of cyclophilin A is increased in patients with type 2 diabetes mellitus and suggests presence of vascular disease. Ramachandran S, et al. Cardiovasc Diabetol, 2014 Feb 7. PMID 24502618 Free PMC Article Knockdown of cyclophilin A reverses paclitaxel resistance in human endometrial cancer cells via suppression of MAPK kinase pathways. Li Z, et al. Cancer Chemother Pharmacol, 2013 Nov. PMID 24036847 Extracellular cyclophilin A protects against blast-induced neuronal injury. Arun P, et al. Neurosci Res, 2013 May-Jun. PMID 23511555 Conformational plasticity of an enzyme during catalysis: intricate coupling between cyclophilin A dynamics and substrate turnover. McGowan LC, et al. Biophys J, 2013 Jan 8. PMID 23332074 Free PMC Article

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CyPA Polyclonal Antibody, 100μg, (ATB-T15197)
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