Cyclin E1 Polyclonal Antibody, 100μg, (ATB-T1177)

Background: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Cyclin E1 Polyclonal Antibody, 100μg, (ATB-T1177) Image Species Reactivities Human Immunogen Synthesized peptide derived from human Cyclin E1 around the non-phosphorylation site of T395. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The 19q12 bladder cancer GWAS signal: association with cyclin E function and aggressive disease. Fu YP, et al. Cancer Res, 2014 Oct 15. PMID 25320178 Cyclin E involved in early stage carcinogenesis of esophageal adenocarcinoma by SNP DNA microarray and immunohistochemical studies. Zhou Z, et al. BMC Gastroenterol, 2014 Apr 17. PMID 24742107 Free PMC Article Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers. Karst AM, et al. Cancer Res, 2014 Feb 15. PMID 24366882 Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma. Kuhn E, et al. Mod Pathol, 2014 Jul. PMID 24309323 Cyclin E1 (CCNE1) as independent positive prognostic factor in advanced stage serous ovarian cancer patients - a study of the OVCAD consortium. Pils D, et al. Eur J Cancer, 2014 Jan. PMID 24176298