Cystatin C Polyclonal Antibody, 100μg, (ATB-T1251)

Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. In addition, this protein has been shown to have an antimicrobial function, inhibiting the replication of herpes simplex virus. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Nov 2014]Product datasheet: Overview Product Description Cystatin C Polyclonal Antibody, 100μg, (ATB-T1251) Image Species Reactivities Human,Mouse,Rat,Monkey Immunogen Synthesized peptide derived from the Internal region of human Cystatin C. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization. Tsiolaki PL, et al. FEBS Lett, 2015 Jan 2. PMID 25479090 Cystatin C, a novel indicator of renal function, reflects severity of cerebral microbleeds. Oh MY, et al. BMC Neurol, 2014 Jun 12. PMID 24925313 Free PMC Article Cystatin-C serum levels and vascular function in heart failure. Tousoulis D, et al. Int J Cardiol, 2014 May 15. PMID 24704396 Plasma cystatin-C and risk of developing gestational diabetes mellitus. Yousefzadeh G, et al. Diabetes Metab Syndr, 2014 Jan-Mar. PMID 24661756 Cigarette smoking and hyperglycemia increase renal response to low levels of cadmium in welders: cystatin C as a sensitive marker. Harisa GI, et al. Biol Trace Elem Res, 2014 Jun. PMID 24652630