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Cytokeratin 8 Polyclonal Antibody, 100μg, (ATB-T15328)

$199.00
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Background: This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]Product datasheet: Overview Product Description Cytokeratin 8 Polyclonal Antibody, 100μg, (ATB-T15328) Image Species Reactivities Human Immunogen Synthesized peptide derived from human Cytokeratin 8 around the non-acetylation site of K483. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Cytokeratin 8 in venous grafts: a factor of unfavorable long-term prognosis in coronary artery bypass grafting patients. Perek B, et al. Cardiol J, 2013. PMID 24338534 Cytokeratin 8 is an epithelial cell receptor for Pet, a cytotoxic serine protease autotransporter of Enterobacteriaceae. Nava-Acosta R, et al. MBio, 2013 Dec 10. PMID 24327340 Free PMC Article Cytokeratin 8-MHC class I interactions: a potential novel immune escape phenotype by a lymph node metastatic carcinoma cell line. Wu MS, et al. Biochem Biophys Res Commun, 2013 Nov 22. PMID 24183726 Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells. Sun MZ, et al. World J Gastroenterol, 2013 Oct 7. PMID 24115814 Free PMC Article Down-regulated CK8 expression in human intervertebral disc degeneration. Sun Z, et al. Int J Med Sci, 2013. PMID 23801880 Free PMC Article

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Cytokeratin 8 Polyclonal Antibody, 100μg, (ATB-T15328)
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