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DD2 Polyclonal Antibody, 100μg, (ATB-T1305)

$199.00
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Background: This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]Product datasheet: Overview Product Description DD2 Polyclonal Antibody, 100μg, (ATB-T1305) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human DD2. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity. Zhang B, et al. J Steroid Biochem Mol Biol, 2014 May. PMID 24434280 Proteomics-based identification of secreted protein dihydrodiol dehydrogenase 2 as a potential biomarker for predicting cisplatin efficacy in advanced NSCLC patients. Kuang P, et al. Lung Cancer, 2012 Aug. PMID 22534668 Glucocorticoid-induced androgen inactivation by aldo-keto reductase 1C2 promotes adipogenesis in human preadipocytes. Veilleux A, et al. Am J Physiol Endocrinol Metab, 2012 Apr 15. PMID 22275760 Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation. Flück CE, et al. Am J Hum Genet, 2011 Aug 12. PMID 21802064 Free PMC Article Residual interactions in unfolded bile acid-binding protein by 19F NMR. Basehore HK, et al. Protein Sci, 2011 Feb. PMID 21280124 Free PMC Article

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DD2 Polyclonal Antibody, 100μg, (ATB-T1305)
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