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DHHC-9 Polyclonal Antibody, 100μg, (ATB-T1344)

$199.00
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Background: This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]Product datasheet: Overview Product Description DHHC-9 Polyclonal Antibody, 100μg, (ATB-T1344) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human DHHC-9. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Mutations in the X-linked intellectual disability gene, zDHHC9, alter autopalmitoylation activity by distinct mechanisms. Mitchell DA, et al. J Biol Chem, 2014 Jun 27. PMID 24811172 [The research on the expression and localization of multiple myeloma associated antigen MMSA-1]. Meng S, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012 Jan. PMID 22230506 DHHC palmitoyl transferases: substrate interactions and (patho)physiology. Greaves J, et al. Trends Biochem Sci, 2011 May. PMID 21388813 Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Mansilla F, et al. Br J Cancer, 2007 Jun 18. PMID 17519897 Free PMC Article Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a Marfanoid habitus. Raymond FL, et al. Am J Hum Genet, 2007 May. PMID 17436253 Free PMC Article

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DHHC-9 Polyclonal Antibody, 100μg, (ATB-T1344)
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