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DNA pol δ cat Polyclonal Antibody, 100μg, (ATB-T1371)

$199.00
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Product Details

Background: This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6. [provided by RefSeq, Mar 2012]Product datasheet: Overview Product Description DNA pol δ cat Polyclonal Antibody, 100μg, (ATB-T1371) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human DNA pol δ cat. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy. Weedon MN, et al. Nat Genet, 2013 Aug. PMID 23770608 Free PMC Article The human lagging strand DNA polymerase δ holoenzyme is distributive. Hu Z, et al. J Biol Chem, 2012 Nov 9. PMID 22942285 Free PMC Article Age-dependent down-regulation of DNA polymerase δ1 in human lymphocytes. Wang JL, et al. Mol Cell Biochem, 2012 Dec. PMID 22915169 Coronavirus infection induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase δ. Xu LH, et al. J Biol Chem, 2011 Nov 11. PMID 21918226 Free PMC Article Identification and functional analysis of a CDE/CHR element in the POLD1 promoter. SONG N, et al. Sci China C Life Sci, 2009 Jun. PMID 19557333

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DNA pol δ cat Polyclonal Antibody, 100μg, (ATB-T1371)
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