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DNAM-1 Polyclonal Antibody, 100μg, (ATB-T1381)

$199.00
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Background: This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]Product datasheet: Overview Product Description DNAM-1 Polyclonal Antibody, 100μg, (ATB-T1381) Image Species Reactivities Human,Mouse,Monkey Immunogen Synthesized peptide derived from human DNAM-1 around the non-phosphorylation site of S329. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: CD226 rs763361 is associated with the susceptibility to type 1 diabetes and greater frequency of GAD65 autoantibody in a Brazilian cohort. Mattana TC, et al. Mediators Inflamm, 2014. PMID 24891767 Free PMC Article CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain. Hou S, et al. J Biol Chem, 2014 Mar 7. PMID 24451371 CD226 rs763361 (Gly307Ser) polymorphism is associated with susceptibility to rheumatoid arthritis in Zahedan, southeast Iran. Hashemi M, et al. Iran Biomed J, 2013. PMID 23999715 Free PMC Article Lack of association between CD226 genetic variants and inflammatory demyelinating diseases in Korean population. Kim JY, et al. Neuro Endocrinol Lett, 2013. PMID 23922043 Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study. Shi S, et al. Gene, 2013 Apr 25. PMID 23262348

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DNAM-1 Polyclonal Antibody, 100μg, (ATB-T1381)
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