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E2F-6 Polyclonal Antibody, 100μg, (ATB-T1446)

$199.00
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Background: This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]Product datasheet: Overview Product Description E2F-6 Polyclonal Antibody, 100μg, (ATB-T1446) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human E2F-6. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors. Wan Z, et al. J Clin Invest, 2010 Oct. PMID 20890043 Free PMC Article Human papillomavirus type 16 E7 oncoprotein associates with E2F6. McLaughlin-Drubin ME, et al. J Virol, 2008 Sep. PMID 18579589 Free PMC Article Comparative analysis of E2F family member oncogenic activity. Chen C, et al. PLoS One, 2007 Sep 19. PMID 17878947 Free PMC Article E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1. Kikuchi J, et al. Stem Cells, 2007 Oct. PMID 17600109 E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. Yang WW, et al. Cell Death Differ, 2007 Apr. PMID 17096023

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E2F-6 Polyclonal Antibody, 100μg, (ATB-T1446)
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