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EDG-1 Polyclonal Antibody, 100μg, (ATB-T1460)

$199.00
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Product Details

Background: The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description EDG-1 Polyclonal Antibody, 100μg, (ATB-T1460) Image Species Reactivities Human Immunogen Synthesized peptide derived from the N-terminal region of human EDG-1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. Borge M, et al. J Immunol, 2014 Sep 15. PMID 25127862 Aberrant expression of sphingosine-1-phosphate receptor 1 correlates with metachronous liver metastasis and poor prognosis in colorectal cancer. Lin Q, et al. Tumour Biol, 2014 Oct. PMID 24972972 Development of a selective S1P1 receptor agonist, Syl930, as a potential therapeutic agent for autoimmune encephalitis. Jin J, et al. Biochem Pharmacol, 2014 Jul 1. PMID 24780445 Structural biology of the S1P1 receptor. Hanson MA, et al. Curr Top Microbiol Immunol, 2014. PMID 24728592 Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis. Sic H, et al. J Allergy Clin Immunol, 2014 Aug. PMID 24679343

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EDG-1 Polyclonal Antibody, 100μg, (ATB-T1460)
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