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EDG-5 Polyclonal Antibody, 100μg, (ATB-T1466)

$199.00
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Background: This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description EDG-5 Polyclonal Antibody, 100μg, (ATB-T1466) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human EDG-5. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: LPS and TNF-α induce expression of sphingosine-1-phosphate receptor-2 in human microvascular endothelial cells. Du J, et al. Pathol Res Pract, 2012 Feb 15. PMID 22244964 S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology. Sumida GM, et al. Am J Physiol Cell Physiol, 2011 May. PMID 21289286 Free PMC Article The S1P(2) receptor expressed in human platelets is linked to the RhoA-Rho kinase pathway and is down regulated in type 2 diabetes. Randriamboavonjy V, et al. Basic Res Cardiol, 2009 May. PMID 19139947 Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Sanchez T, et al. Arterioscler Thromb Vasc Biol, 2007 Jun. PMID 17431187 Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. Osada M, et al. Biochem Biophys Res Commun, 2002 Dec 6. PMID 12445827

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EDG-5 Polyclonal Antibody, 100μg, (ATB-T1466)
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