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EKLF Polyclonal Antibody, 100μg, (ATB-T15425)

$199.00
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Product Details

Background: This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]Product datasheet: Overview Product Description EKLF Polyclonal Antibody, 100μg, (ATB-T15425) Image Species Reactivities Human Immunogen Synthesized peptide derived from human EKLF around the non-acetylation site of K274. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: KLF1 mutations are relatively more common in a thalassemia endemic region and ameliorate the severity of β-thalassemia. Liu D, et al. Blood, 2014 Jul 31. PMID 24829204 [Screening of rare blood group Lu(a-b-) phenotype and study of its molecular basis in ethnic Han Chinese from Shanghai region]. Wang C, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2014 Apr. PMID 24711040 Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression. Viprakasit V, et al. Blood, 2014 Mar 6. PMID 24443441 KLF1 gene mutations in Chinese adults with increased fetal hemoglobin. Wang T, et al. Hemoglobin, 2013. PMID 23806141 Three fingers on the switch: Krüppel-like factor 1 regulation of γ-globin to β-globin gene switching. Tallack MR, et al. Curr Opin Hematol, 2013 May. PMID 23474875

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EKLF Polyclonal Antibody, 100μg, (ATB-T15425)
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