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ERAP1 Polyclonal Antibody, 100μg, (ATB-T1606)

$199.00
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Product Details

Background: The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]Product datasheet: Overview Product Description ERAP1 Polyclonal Antibody, 100μg, (ATB-T1606) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human ERAP1. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis. Reeves E, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25422414 Free PMC Article Protective effect of an ERAP1 haplotype in ankylosing spondylitis: investigating non-MHC genes in HLA-B27-positive individuals. Bettencourt BF, et al. Rheumatology (Oxford), 2013 Dec. PMID 24046467 A polymorphism in ERAP1 is associated with susceptibility to ankylosing spondylitis in a Turkish population. Cinar M, et al. Rheumatol Int, 2013 Nov. PMID 23864143 Naturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity. Reeves E, et al. J Immunol, 2013 Jul 1. PMID 23733883 Free PMC Article ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role. Alvarez-Navarro C, et al. Curr Opin Rheumatol, 2013 Jul. PMID 23656713

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ERAP1 Polyclonal Antibody, 100μg, (ATB-T1606)
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