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ERp57 Polyclonal Antibody, 100μg, (ATB-T15220)

$199.00
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Background: This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description ERp57 Polyclonal Antibody, 100μg, (ATB-T15220) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human ERp57. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Modulation of H(+),K(+)-ATPase activity by the molecular chaperone ERp57 highly expressed in gastric parietal cells. Fujii T, et al. FEBS Lett, 2013 Dec 11. PMID 24188822 Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer. Chung H, et al. Biomarkers, 2013 Nov. PMID 23957851 Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset. Dihazi H, et al. J Cell Sci, 2013 Aug 15. PMID 23781031 A transcriptome-proteome integrated network identifies endoplasmic reticulum thiol oxidoreductase (ERp57) as a hub that mediates bone metastasis. Santana-Codina N, et al. Mol Cell Proteomics, 2013 Aug. PMID 23625662 Free PMC Article ERp57/PDIA3 binds specific DNA fragments in a melanoma cell line. Aureli C, et al. Gene, 2013 Jul 25. PMID 23587917

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ERp57 Polyclonal Antibody, 100μg, (ATB-T15220)
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