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Elk-1 Polyclonal Antibody, 100μg, (ATB-T1528)

$199.00
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Background: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]Product datasheet: Overview Product Description Elk-1 Polyclonal Antibody, 100μg, (ATB-T1528) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Elk-1 around the non-phosphorylation site of S389. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene. Bruck T, et al. Cell Rep, 2013 Jul 25. PMID 23871667 Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features. Laliotis A, et al. Breast, 2013 Feb. PMID 23127278 Elk-1 phosphorylated at threonine-417 is present in diverse cancers and correlates with differentiation grade of colonic adenocarcinoma. Morris JF, et al. Hum Pathol, 2013 May. PMID 23114923 ELK1 uses different DNA binding modes to regulate functionally distinct classes of target genes. Odrowaz Z, et al. PLoS Genet, 2012. PMID 22589737 Free PMC Article Effects of resistance exercise intensity on extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase activation in men. Taylor LW, et al. J Strength Cond Res, 2012 Mar. PMID 22343976

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Elk-1 Polyclonal Antibody, 100μg, (ATB-T1528)
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