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FGF-20 Polyclonal Antibody, 100μg, (ATB-T15178)

$199.00
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Background: The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]Product datasheet: Overview Product Description FGF-20 Polyclonal Antibody, 100μg, (ATB-T15178) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human FGF-20. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Fibroblast growth factor 20 polymorphism in sporadic Parkinson's disease in Northern Han Chinese. Xu X, et al. J Clin Neurosci, 2013 Nov. PMID 23938014 [Analysis of the rs12720208 single-nucleotide polymorphism of the FGF20 gene in Russian patients with sporadic Parkinson's disease]. Ustinova VV, et al. Genetika, 2012 Dec. PMID 23516905 Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson's disease in Chinese population. Pan J, et al. Parkinsonism Relat Disord, 2012 Jun. PMID 22342445 Genetic variation in FGF20 modulates hippocampal biology. Lemaitre H, et al. J Neurosci, 2010 Apr 28. PMID 20427658 Free PMC Article Effects of pH and arginine on the solubility and stability of a therapeutic protein (Fibroblast Growth Factor 20): relationship between solubility and stability. Maity H, et al. Curr Pharm Biotechnol, 2009 Sep. PMID 19619121

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FGF-20 Polyclonal Antibody, 100μg, (ATB-T15178)
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