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FGF-5 Polyclonal Antibody, 100μg, (ATB-T15190)

$199.00
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Background: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description FGF-5 Polyclonal Antibody, 100μg, (ATB-T15190) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human FGF-5. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: FGF5 is a crucial regulator of hair length in humans. Higgins CA, et al. Proc Natl Acad Sci U S A, 2014 Jul 22. PMID 24989505 Free PMC Article Splicing of distant peptide fragments occurs in the proteasome by transpeptidation and produces the spliced antigenic peptide derived from fibroblast growth factor-5. Dalet A, et al. J Immunol, 2010 Mar 15. PMID 20154207 FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. Allerstorfer S, et al. Oncogene, 2008 Jul 10. PMID 18362893 Free PMC Article Technology evaluation: gene therapy (FGF-5), Vical. Li K, et al. Curr Opin Mol Ther, 1999 Apr. PMID 11715949 Identification of fibroblast growth factor-5 as an overexpressed antigen in multiple human adenocarcinomas. Hanada K, et al. Cancer Res, 2001 Jul 15. PMID 11454700

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FGF-5 Polyclonal Antibody, 100μg, (ATB-T15190)
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