FMO3 Polyclonal Antibody, 100μg, (ATB-T15453)

Background: Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Aug 2009]Product datasheet: Overview Product Description FMO3 Polyclonal Antibody, 100μg, (ATB-T15453) Image Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human FMO3. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Effects of single-nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor. Park S, et al. Drug Metab Dispos, 2014 Jan. PMID 24173915 Relationships between flavin-containing mono-oxygenase 3 (FMO3) genotype and trimethylaminuria phenotype in a Japanese population. Shimizu M, et al. Br J Clin Pharmacol, 2014 May. PMID 24028545 Trimethylaminuria (fish odor syndrome): genotype characterization among Portuguese patients. Ferreira F, et al. Gene, 2013 Sep 15. PMID 23791655 Survey of variants of human flavin-containing monooxygenase 3 (FMO3) and their drug oxidation activities. Yamazaki H, et al. Biochem Pharmacol, 2013 Jun 1. PMID 23567996 Flavin containing monooxygenase 3 genetic polymorphisms Glu158Lys and Glu308Gly and their relation to ischemic stroke. Türkanoğlu Özçelik A, et al. Gene, 2013 May 25. PMID 23510775