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FOXP3 Polyclonal Antibody, 100μg, (ATB-T15446)

$199.00
In stock
Product Details

Background: The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description FOXP3 Polyclonal Antibody, 100μg, (ATB-T15446) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human FOXP3. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis. Bending D, et al. J Immunol, 2014 Sep 15. PMID 25092890 Free PMC Article A novel upstream enhancer of FOXP3, sensitive to methylation-induced silencing, exhibits dysregulated methylation in rheumatoid arthritis Treg cells. Kennedy A, et al. Eur J Immunol, 2014 Oct. PMID 25042153 Higher FOXP3-TSDR demethylation rates in adjacent normal tissues in patients with colon cancer were associated with worse survival. Zhuo C, et al. Mol Cancer, 2014 Jun 18. PMID 24938080 Free PMC Article FOXP3 transcription factor: a candidate marker for susceptibility and prognosis in triple negative breast cancer. Lopes LF, et al. Biomed Res Int, 2014. PMID 24877082 Free PMC Article Lactobacillus reuteri DSM 17938 differentially modulates effector memory T cells and Foxp3+ regulatory T cells in a mouse model of necrotizing enterocolitis. Liu Y, et al. Am J Physiol Gastrointest Liver Physiol, 2014 Jul 15. PMID 24852566

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FOXP3 Polyclonal Antibody, 100μg, (ATB-T15446)
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