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Factor VIII Polyclonal Antibody, 100μg, (ATB-T1653)
Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Factor VIII Polyclonal Antibody, 100μg, (ATB-T1653) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the C-terminal region of human Factor VIII. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs. Park CY, et al. Proc Natl Acad Sci U S A, 2014 Jun 24. PMID 24927536 Free PMC Article Mutations in intron 1 and intron 22 inversion negative haemophilia A patients from Western India. Nair PS, et al. PLoS One, 2014. PMID 24845853 Free PMC Article Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS. Pantazatos D, et al. Biochem J, 2014 Aug 1. PMID 24814520 Acute cerebral infarct with elevated factor VIII level during the thrombocytopenic stage after hematopoietic stem cell transplant. Hsiao HH, et al. Exp Clin Transplant, 2014 Apr. PMID 24702151 Higher frequency of CD4(+)CD25(high) Treg cells in hemophilia patients with factor VIII inhibitor. Ding KY, et al. Genet Mol Res, 2014 Mar 17. PMID 24668665
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IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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