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Frizzled-10 Polyclonal Antibody, 100μg, (ATB-T1775)

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Background: This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Frizzled-10 Polyclonal Antibody, 100μg, (ATB-T1775) Image Species Reactivities Human,Mouse,Monkey Immunogen Synthesized peptide derived from the Internal region of human Frizzled-10. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors. Carmon KS, et al. Anal Biochem, 2010 Jun 15. PMID 20227380 Free PMC Article Transcriptional profiling and Wnt signaling activation in proliferation of human hepatic stellate cells induced by PDGF-BB. Shin HW, et al. Korean J Hepatol, 2009 Dec. PMID 20037267 Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. Nagayama S, et al. Cancer Sci, 2009 Mar. PMID 19134005 Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. Fukukawa C, et al. Cancer Sci, 2008 Feb. PMID 18271942 Therapeutic potential of antibodies against FZD 10, a cell-surface protein, for synovial sarcomas. Nagayama S, et al. Oncogene, 2005 Sep 15. PMID 16007199

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Frizzled-10 Polyclonal Antibody, 100μg, (ATB-T1775)