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Frizzled-7 Polyclonal Antibody, 100μg, (ATB-T1786)
Background: Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Frizzled-7 Polyclonal Antibody, 100μg, (ATB-T1786) Image Species Reactivities Human,Mouse Immunogen Synthesized peptide derived from the N-terminal region of human Frizzled-7. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Fernandez A, et al. Proc Natl Acad Sci U S A, 2014 Jan 28. PMID 24474766 Free PMC Article Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells. Mei H, et al. Stem Cells, 2014 Apr. PMID 24170316 FZD7 has a critical role in cell proliferation in triple negative breast cancer. Yang L, et al. Oncogene, 2011 Oct 27. PMID 21532620 Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Ueno K, et al. Br J Cancer, 2009 Oct 20. PMID 19773752 Free PMC Article Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment. Vincan E, et al. Dev Dyn, 2010 Jan. PMID 19655379
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Why is IntelixBio LLC so popular?
IntelixBio has swiftly become a household name in the medical industry, primarily owing to its cutting-edge medical lab equipment. Our commitment to excellence resonates through every facet of our products, ensuring that laboratories worldwide receive top-tier solutions for their diagnostic needs. Our medical lab equipment is engineered with precision and innovation, embodying the pinnacle of technological advancement in the field. From state-of-the-art analyzers to automated specimen-handling systems, our extensive catalog caters to diverse laboratory requirements, fostering efficiency and accuracy in every diagnostic process. Laboratories entrust IntelixBio's medical lab equipment for its unwavering reliability, empowering healthcare professionals with the tools they need to deliver optimal patient care.
At IntelixBio, our dedication to advancing healthcare is exemplified through our unparalleled range of medical lab equipment. Each product is meticulously crafted to meet the exacting standards of modern laboratory environments, facilitating seamless integration and operation. Our commitment to quality permeates every aspect of our offerings, ensuring that laboratories can consistently rely on our medical lab equipment to deliver precise and dependable results. With a comprehensive selection that spans from basic laboratory essentials to sophisticated diagnostic instruments, IntelixBio remains the foremost choice for institutions seeking excellence in medical equipment solutions. Trust IntelixBio to elevate your laboratory capabilities with our innovative medical lab equipment, empowering you to drive progress in healthcare delivery.
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What products do you offer?
At IntelixBio LLC, we offer high-quality medical lab equipment. Our lab supplies include:
- Protective gear
- Antibody immunodetection supplies
- Bioreagents
- Lab Supplies
- Immunohistochemistry Tools
- Instruments and Equipment
- PPE
- Sample preparation supplies
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Where do you ship your medical lab equipment?
We ship our medical lab equipment to customers nationwide. Browse our online shop to view our impressive inventory of available lab equipment today and purchase the products that meet your unique style and needs. We can't wait to prove why Intelixbio.com is one of the nation's best medical lab supply providers.
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How can I contact your company?
You can reach IntelixBio LLC by phone at 240-316-3161, by email at info@intelixbio.com, or by filling out one of the contact forms on our website.
When you contact our team, you can expect fast, friendly, and professional assistance with all your medical lab equipment needs.