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GPR132 Polyclonal Antibody, 100μg, (ATB-T1968)

$199.00
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Background: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]Product datasheet: Overview Product Description GPR132 Polyclonal Antibody, 100μg, (ATB-T1968) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human GPR132. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Ellison MA, et al. Curr Pharm Des, 2012. PMID 22621271 Free PMC Article Lysophosphatidylcholines activate G2A inducing G(αi)₋₁-/G(αq/)₁₁- Ca²(+) flux, G(βγ)-Hck activation and clathrin/β-arrestin-1/GRK6 recruitment in PMNs. Khan SY, et al. Biochem J, 2010 Nov 15. PMID 20799926 Free PMC Article Identification and analysis of two splice variants of human G2A generated by alternative splicing. Ogawa A, et al. J Pharmacol Exp Ther, 2010 Feb. PMID 19855098 Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. Peter C, et al. J Biol Chem, 2008 Feb 29. PMID 18089568 G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid. Hattori T, et al. J Invest Dermatol, 2008 May. PMID 18034171

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GPR132 Polyclonal Antibody, 100μg, (ATB-T1968)