GRIP-1 Polyclonal Antibody, 100μg, (ATB-T2062)

Background: The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]Product datasheet: Overview Product Description GRIP-1 Polyclonal Antibody, 100μg, (ATB-T2062) Species Reactivities Human Immunogen Synthesized peptide derived from human GRIP-1 around the non-phosphorylation site of S736. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. Szwarc MM, et al. PLoS One, 2014. PMID 24905738 Free PMC Article Downregulation of steroid receptor coactivator-2 modulates estrogen-responsive genes and stimulates proliferation of mcf-7 breast cancer cells. Fenne IS, et al. PLoS One, 2013. PMID 23936147 Free PMC Article Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma. Mosquera JM, et al. Genes Chromosomes Cancer, 2013 Jun. PMID 23463663 Free PMC Article Mutational analysis of NCOA2 gene in prostate cancer and other common cancers. An CH, et al. APMIS, 2011 Apr. PMID 21492233 The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. Schmelzer C, et al. J Med Food, 2011 Apr. PMID 21370964