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GROα Polyclonal Antibody, 100μg, (ATB-T2074)

$199.00
In stock
Product Details

Background: This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]Product datasheet: Overview Product Description GROα Polyclonal Antibody, 100μg, (ATB-T2074) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the Internal region of human GROα. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: CXCL1 is a negative regulator of mast cell chemotaxis to airway smooth muscle cell products in vitro. Alkhouri H, et al. Clin Exp Allergy, 2014 Mar. PMID 24588865 Influence of the CXCL1 rs4074 A allele on alcohol induced cirrhosis and HCC in patients of European descent. Nischalke HD, et al. PLoS One, 2013. PMID 24260493 Free PMC Article CXCL1 expression in human decidua in vitro is mediated via the MAPK signalling cascade. Baston-Büst DM, et al. Cytokine, 2013 Oct. PMID 23953856 Chemokine (C-X-C) ligand 1 (CXCL1) protein expression is increased in aggressive bladder cancers. Miyake M, et al. BMC Cancer, 2013 Jul 1. PMID 23815949 Free PMC Article Expression of CXCL1 in human endothelial cells induces angiogenesis through the CXCR2 receptor and the ERK1/2 and EGF pathways. Miyake M, et al. Lab Invest, 2013 Jul. PMID 23732813

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GROα Polyclonal Antibody, 100μg, (ATB-T2074)
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