Histone H4 Polyclonal Antibody, 100µg, (ATB-T2175)

Background: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Product datasheet: Overview Product Description Histone H4 Polyclonal Antibody, 100µg, (ATB-T2175) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human Histone H4 around the non-phosphorylation site of S47. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Structure and in vitro transcription of a human H4 histone gene. Sierra F., Stein G., Stein J.Nucleic Acids Res. 11:7069-7086(1983) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene. Pauli U., Chrysogelos S., Stein G., Stein J., Nick H.Science 236:1308-1311(1987) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Albig W., Kardalinou E., Drabent B., Zimmer A., Doenecke D.Genomics 10:940-948(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: Placenta. Association of histone H4 genes with the mammalian testis-specific H1t histone gene. Drabent B., Kardalinou E., Bode C., Doenecke D.DNA Cell Biol. 14:591-597(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Characterization of the H1.5 gene completes the set of human H1 subtype genes. Albig W., Meergans T., Doenecke D.Gene 184:141-148(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. The human histone gene cluster at the D6S105 locus. Albig W., Doenecke D.Hum. Genet. 101:284-294(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Human histone gene organization: nonregular arrangement within a large cluster. Albig W., Kioschis P., Poustka A., Meergans K., Doenecke D.Genomics 40:314-322(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. The human and mouse replication-dependent histone genes. Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.Genomics 80:487-498(2002) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIST1H4A; HIST1H4B; HIST1H4C; HIST1H4D; HIST1H4E; HIST1H4F; HIST1H4H; HIST1H4I; HIST1H4J; HIST1H4K; HIST1H4L; HIST2H4A AND HIST4H4). A recurring translocation, t(3;6)(q27;p21), in non-Hodgkin's lymphoma results in replacement of the 5' regulatory region of BCL6 with a novel H4 histone gene. Akasaka T., Miura I., Takahashi N., Akasaka H., Yonetani N., Ohno H., Fukuhara S., Okuma M.Cancer Res. 57:7-12(1997) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Functional characterization of a human histone gene cluster duplication. Braastad C.D., Hovhannisyan H., van Wijnen A.J., Stein J.L., Stein G.S.Gene 342:35-40(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].