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HoxA5 Polyclonal Antibody, 100μg, (ATB-T2211)

$199.00
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Product Details

Background: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description HoxA5 Polyclonal Antibody, 100μg, (ATB-T2211) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the N-terminal region of human HoxA5. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: HOXA5 inhibits keratinocytes growth and epidermal formation in organotypic cultures in vitro and in vivo. Liang Y, et al. J Dermatol Sci, 2012 Jun. PMID 22464764 Homeobox gene expression profile indicates HOXA5 as a candidate prognostic marker in oral squamous cell carcinoma. Rodini CO, et al. Int J Oncol, 2012 Apr. PMID 22227861 Free PMC Article Level of HOXA5 hypermethylation in acute myeloid leukemia is associated with short-term outcome. Kim SY, et al. Korean J Lab Med, 2010 Oct. PMID 20890077 Epigenetic inactivation of Homeobox A5 gene in nonsmall cell lung cancer and its relationship with clinicopathological features. Kim DS, et al. Mol Carcinog, 2009 Dec. PMID 19554572 Expression pattern of a homeotic gene, HOXA5, in normal breast and in breast tumors. Henderson GS, et al. Cell Oncol, 2006. PMID 17167183

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HoxA5 Polyclonal Antibody, 100μg, (ATB-T2211)
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