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HoxD8 Polyclonal Antibody, 100μg, (ATB-T2221)

$199.00
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Background: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]Product datasheet: Overview Product Description HoxD8 Polyclonal Antibody, 100μg, (ATB-T2221) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human HoxD8. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Dinucleotide repeat polymorphism in the HOX4E locus. Rosen DR, et al. Hum Mol Genet, 1993 May. PMID 8100165 Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation. Manohar CF, et al. Tumour Biol, 1996. PMID 7501971 Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. Redline RW, et al. Genomics, 1992 Jun. PMID 1351871 Complementary homeo protein gradients in developing limb buds. Oliver G, et al. Genes Dev, 1989 May. PMID 2568311 Limb malformations and the human HOX genes. Goodman FR. Am J Med Genet, 2002 Oct 15. PMID 12357469

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HoxD8 Polyclonal Antibody, 100μg, (ATB-T2221)
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