IL-12B Polyclonal Antibody, 100µg, (ATB-T2312)

Background: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Product datasheet: Overview Product Description IL-12B Polyclonal Antibody, 100µg, (ATB-T2312) Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human IL-12B. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Gubler U., Chua A.O., Schoenhaut D.S., Dwyer C.M., McComas W., Motyka R., Nabavi N., Wolitzky A.G., Quinn P.M., Familletti P.C., Gately M.K.Proc. Natl. Acad. Sci. U.S.A. 88:4143-4147(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. Wolf S.F., Temple P.A., Kobayashi M., Young D., Dicig M., Lowe L., Dzialo R., Fitz L., Ferenz C., Hewick R.M., Kelleher K., Herrmann S.H., Clark S.C., Azzoni L., Chan S.H., Trinchieri G., Perussia B.J. Immunol. 146:3074-3081(1991) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Complete primary structure, chromosomal localization, and definition of polymorphisms of the gene encoding the human interleukin 12 p40 subunit. Huang D., Cancilla M.R., Morahan G.Genes Immun. 1:515-520(2000) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Cloning and sequence analysis of IL-12 cDNA from Chinese. Hongyuan J., Meiyun Z.Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA]. SeattleSNPs variation discovery resourceSubmitted (MAY-2002) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ILE-33 AND PHE-298. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Stern A.S., Podlaski F.J., Hulmes J.D., Pan Y.C.E., Quinn P.M., Wolitzky A.G., Familletti P.C., Stremlo D.L., Truitt T., Chizzonite R., Gately M.K.Proc. Natl. Acad. Sci. U.S.A. 87:6808-6812(1990) [PubMed] [Europe PMC] Cited for: PROTEIN SEQUENCE OF 23-45. Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. Gearing D.P., Cosman D.Cell 66:9-10(1991) [PubMed] [Europe PMC] Cited for: SIMILARITY TO IL-6 RECEPTOR. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. D'Andrea A., Ma X., Aste-Amezaga M., Paganin C., Trinchieri G.J. Exp. Med. 181:537-546(1995) [PubMed] [Europe PMC] Cited for: SUBUNIT. Recombinant human interleukin-12 is the second example of a C-mannosylated protein. Doucey M.A., Hess D., Blommers M.J., Hofsteenge J.Glycobiology 9:435-441(1999) [PubMed] [Europe PMC] Cited for: GLYCOSYLATION AT TRP-319.