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IL-15Rα Polyclonal Antibody, 100μg, (ATB-T2315)

$199.00
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Product Details

Background: This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.[provided by RefSeq, Apr 2010]Product datasheet: Overview Product Description IL-15Rα Polyclonal Antibody, 100μg, (ATB-T2315) Image Species Reactivities Human,Rat Immunogen Synthesized peptide derived from the Internal region of human IL-15Rα. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Interleukin 15 receptor alpha rs2228059 A > C polymorphism decreased risk of gastric cardiac adenocarcinoma in a Chinese population. Yin J, et al. Tumour Biol, 2014 Jul. PMID 24696261 IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Yin J, et al. Mol Biol Rep, 2014. PMID 24464181 Interleukin-15 receptor α expression in inflammatory bowel disease patients before and after normalization of inflammation with infliximab. Perrier C, et al. Immunology, 2013 Jan. PMID 23039249 Free PMC Article Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia. Chen J, et al. Blood, 2012 Jan 5. PMID 22049515 Free PMC Article Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament. Kim DH, et al. Cytokine, 2011 Sep. PMID 21689944

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IL-15Rα Polyclonal Antibody, 100μg, (ATB-T2315)
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