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IL-28 Polyclonal Antibody, 100μg, (ATB-T15305)

$199.00
In stock
Product Details

Background: This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description IL-28 Polyclonal Antibody, 100μg, (ATB-T15305) Image Species Reactivities Human Immunogen Synthesized peptide derived from the C-terminal region of human IL-28. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease. Li B, et al. Cell Immunol, 2014 Jul. PMID 24973639 Interleukin-28A triggers wound healing migration of bladder cancer cells via NF-κB-mediated MMP-9 expression inducing the MAPK pathway. Lee SJ, et al. Cell Signal, 2012 Sep. PMID 22560878 Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Zhu H, et al. Virol J, 2005 Sep 7. PMID 16146571 Free PMC Article Role of the p38 MAPK signaling pathway in mediating interleukin-28A-induced migration of UMUC-3 cells. Lee SJ, et al. Int J Mol Med, 2012 Oct. PMID 22825757 Sequence analysis of the IL28A/IL28B inverted gene duplication that contains polymorphisms associated with treatment response in hepatitis C patients. Reynolds JM, et al. PLoS One, 2012. PMID 22253847 Free PMC Article

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IL-28 Polyclonal Antibody, 100μg, (ATB-T15305)
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