IL-4 Polyclonal Antibody, 100µg, (ATB-T2334)

Background: Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.Product datasheet: Overview Product Description IL-4 Polyclonal Antibody, 100µg, (ATB-T2334) Species Reactivities Human Immunogen Synthesized peptide derived from the Internal region of human IL-4. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year Clonality Polyclonal References: Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Yokota T., Otsuka T., Mosmann T., Banchereau J., Defrance T., Blanchard D., de Vries J.E., Lee F., Arai K.Proc. Natl. Acad. Sci. U.S.A. 83:5894-5898(1986) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. Arai N., Nomura D., Villaret D., Malefijt R.D., Seiki M., Yoshida M., Minoshima S., Fukuyama R., Maekawa M., Kudoh J., Shimizu N., Yokota K., Abe E., Yokota T., Takebe Y., Arai K.J. Immunol. 142:274-282(1989) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. An alternatively spliced interleukin 4 form in lymphoid cells. Klein S.C., Golverdingen J., Bouwens A.G.M., Tilanus M.G.J.Immunogenetics 41:57-57(1995) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). SeattleSNPs variation discovery resourceSubmitted (JUN-2001) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). The MGC Project TeamGenome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Blood. The 5' region of the human interleukin 4 gene: structure and potential regulatory elements. Eder A., Krafft-Czepa H., Krammer P.H.Nucleic Acids Res. 16:772-772(1988) [PubMed] [Europe PMC] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45. Disulfide assignments in recombinant mouse and human interleukin 4. Carr C., Aykent S., Kimack N.M., Levine A.D.Biochemistry 30:1515-1523(1991) [PubMed] [Europe PMC] Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-62, DISULFIDE BONDS. Crystal structure of recombinant human interleukin-4. Walter M.R., Cook W.J., Zhao B.G., Cameron R.P. Jr., Ealick S.E., Walter R.L. Jr., Reichert P., Nagabhushan T.L., Trotta P.P., Bugg C.E.J. Biol. Chem. 267:20371-20376(1992) [PubMed] [Europe PMC] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS). Crystal structure of human recombinant interleukin-4 at 2.25-A resolution. Wlodaver A., Pavlovsky A., Gustchina A.FEBS Lett. 309:59-64(1992) [PubMed] [Europe PMC] Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS). Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Hage T., Sebald W., Reinemer P.Cell 97:271-281(1999) [PubMed] [Europe PMC] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 25-153 IN COMPLEX WITH IL4RALPHA.