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IRAK-1 Polyclonal Antibody, 100μg, (ATB-T2390)

$199.00
In stock
Product Details

Background: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description IRAK-1 Polyclonal Antibody, 100μg, (ATB-T2390) Species Reactivities Human Immunogen Synthesized peptide derived from human IRAK-1 around the non-phosphorylation site of S376. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: X chromosome-linked IRAK-1 polymorphism is a strong predictor of multiple organ failure and mortality postinjury. Sperry JL, et al. Ann Surg, 2014 Oct. PMID 25203887 Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling. Stürner KH, et al. Eur J Immunol, 2014 Apr. PMID 24469975 Association of interleukin-1 receptor-associated kinase (IRAK1) gene polymorphisms (rs3027898, rs1059702) with systemic lupus erythematosus in a Chinese Han population. Zhai Y, et al. Inflamm Res, 2013 Jun. PMID 23435933 Role of IRAK1 on TNF-induced proliferation and NF-ĸB activation in human bone marrow mesenchymal stem cells. Kim JM, et al. Cell Physiol Biochem, 2012. PMID 22759955 IRAK1 rs3027898 C/A polymorphism is associated with risk of rheumatoid arthritis. Zhang H, et al. Rheumatol Int, 2013 Feb. PMID 22451023

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IRAK-1 Polyclonal Antibody, 100μg, (ATB-T2390)
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