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Inhibin β-B Polyclonal Antibody, 100μg, (ATB-T15408)

$199.00
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Background: The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description Inhibin β-B Polyclonal Antibody, 100μg, (ATB-T15408) Image Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from the C-terminal region of human Inhibin β-B. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome. Shayya RF, et al. Fertil Steril, 2014 Jan. PMID 24188875 Free PMC Article Inhibin B levels in hypothyroid males. Donnelly P, et al. Thyroid, 2013 Nov. PMID 23692058 Inhibin B in plasma samples from male volunteer panel selected for health but not fertility: sources of variability. Stewart J, et al. Birth Defects Res B Dev Reprod Toxicol, 2013 Feb. PMID 23349064 Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene. Johnson MP, et al. PLoS One, 2012. PMID 22432041 Free PMC Article Inhibin beta B: a useful tumor marker in uterine endometrioid adenocarcinomas? Mylonas I. Histol Histopathol, 2011 Nov. PMID 21938679

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Inhibin β-B Polyclonal Antibody, 100μg, (ATB-T15408)
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