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JAK2 Polyclonal Antibody, 100μg, (ATB-T2427)

$199.00
In stock
Product Details

Background: This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]Product datasheet: Overview Product Description JAK2 Polyclonal Antibody, 100μg, (ATB-T2427) Species Reactivities Human,Mouse,Rat Immunogen Synthesized peptide derived from human JAK2 around the non-phosphorylation site of Y931. Properties Form Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions-20°C/1 year References: Distinct driver mutation profiles of childhood and adolescent essential thrombocythemia. Langabeer SE, et al. Pediatr Blood Cancer, 2015 Jan. PMID 25132652 Interferon α-2b gains high sustained response therapy for advanced essential thrombocythemia and polycythemia vera with JAK2V617F positive mutation. Huang BT, et al. Leuk Res, 2014 Oct. PMID 25069759 The role of serum erythropoietin level and JAK2 V617F allele burden in the diagnosis of polycythaemia vera. Ancochea A, et al. Br J Haematol, 2014 Nov. PMID 25040297 The JAK2 46/1 haplotype (GGCC) in myeloproliferative neoplasms and splanchnic vein thrombosis: a pooled analysis of 26 observational studies. Li SL, et al. Ann Hematol, 2014 Nov. PMID 25015051 Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase. Shan Y, et al. Nat Struct Mol Biol, 2014 Jul. PMID 24918548

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JAK2 Polyclonal Antibody, 100μg, (ATB-T2427)
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